Drug Interactions

Inform your doctor about all the medicines you use, (prescription and nonprescription) especially if you take high blood pressure medicine or MAO inhibitors (e.g., furazolidone, phenelzine, selegiline, tranylcypromine) or any other weight loss medicine. Decongestants are commonly found in over-the-counter cough and cold medicine.

Possible Side Effects: Mild

Blurred vision, dry mouth, sleeplessness, irritability, stomach upset or constipation may occur the first few days as your body adjusts to the medication. Other adverse events include central nervous system effects, gastrointestinal disturbances, and changes in libido. If these effects persist or become bothersome, you may have to discontinue use. Exercise caution when prescribing anti-obesity drugs for patients with hypertension. If this medication makes you dizzy or lightheaded, avoid driving or engaging in activities requiring alertness. Alcohol can increase unwanted side effects of dizziness. Limit its use.

Possible Side Effects: Moderate

Chest pain, pounding heart, difficulty urinating, breathing difficulties or swelling while taking this medication.

Possible Side Effects: Severe

Primary pulmonary hypertension (PPH) and cardiac valvular disease have been reported in patients receiving a combination of phentermine and fenfluramine (phen-fen) or dexfenfluramine. The possibility of an association between PPH and the use of Phentermine alone cannot be ruled out.

Contraindications

Phentermine is contraindicated in patients with arteriosclerosis, cardiovascular disease, and moderate to severe hypertension.

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